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The Nordman Lab

at Southern Illinois University School of Medicine

Jess Jacobs, Ph.D.


Keystone Grant Awardee


Jessica T. Jacobs, PhD is a Senior Scientist and Education Assistant Professor in the Division of Physiology at Southern Illinois University School of Medicine. In the Nordman Lab, she investigates how brain circuits regulate social behavior and how stress alters their function. Her research combines targeted manipulations of neural pathways with detailed behavioral analysis to understand how experience shapes social interactions.
Dr. Jacobs teaches courses in neurobiology and serves as an instructor in the School of Medicine’s problem-based learning curriculum. Her commitment to teaching and mentorship spans her work in the classroom and the lab, helping students connect neuroscience research with broader questions about behavior and health.
She earned her PhD in Neuroscience from Georgetown University, where she studied the neural mechanisms of social behavior in nonhuman primates with Ludise Malkova and Patrick Forcelli. Before her doctoral training, she was an IRTA fellow at the National Institute of Mental Health. Her background in psychology and philosophy, alongside research across species, informs her approach to both science and education.

2026




Traumatic stress recruits an excitatory orbitofrontal–amygdala pathway to drive maladaptive aggression.


Mikaela L. Aholt, Jessica T. Jacobs, Magdalene P. Adjei, Nooshin Mojahed, Elana Qasem, Sandria W. Athul, Buffy Ellsworth, Jacob C. Nordman

Neuropsychopharmacology




The anterior BNST is required for novelty-driven social interaction


Jessica T. Jacobs, Mikaela L. Aholt, Taylor Lineberry, Magdalene P. Adjei, Elana Qasem, Sophia Aaflaq, Sandria W. Athul, Buffy S. Ellsworth, Jacob C. Nordman

The Journal of Neuroscience, 2026, pp. e1743252026


2025




Familiarity gates socially transmitted aggression via the medial amygdala


Magdalene P. Adjei, Elana Qasem, Sophia Aaflaq, Jessica T. Jacobs, Savannah Skinner, Fletcher Summa, Claudia Spotanski, Rylee Thompson, Mikaela L. Aholt, Taylor Lineberry, Jacob C. Nordman

Journal of Neuroscience, 2025


2024




Acute social defeat during adolescence promotes long-lasting aggression through activation of the medial amygdala


Nooshin Mojahed, Magdalene Pine Adjei, Elana Qasem, Sophia Aaflaq, Jessica T. Jacobs, Temitope Adu, Ben Richardson, Jacob C. Nordman,

Frontiers in Neuroscience, vol. 18, 2024


2023




A single dose of ketamine enhances early life stress-induced aggression with no effect on fear memory, anxiety-like behavior, or depression-like behavior in mice.


C. J. Bartsch, S. Aaflaq, J. T. Jacobs, M. Smith, F. Summa, S. Skinner, E. Qasem, R. Thompson, Z. Li, J. C. Nordman

Behavioral Neuroscience, 2023




Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP


Caitlyn J. Bartsch, Jessica T. Jacobs, Nooshin Mojahed, Elana Qasem, Molly Smith, Oliver Caldwell, Sophia Aaflaq, Jacob C. Nordman

Frontiers in Molecular Neuroscience, vol. 16, 2023


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